A study of the efficacy of transperineal ultrasonography in earlier diagnosis of ulcerative colitis in children.

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K16905
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52050:Embryonic medicine and pediatrics-related
• Research Institution: Juntendo University
• Principal Investigator: Jimbo Keisuke 順天堂大学, 医学部, 助教 (80772350)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 経会陰超音波検査 / 潰瘍性大腸炎 / 小児 / ドップラー血流 / 直腸壁厚

Outline of Final Research Achievements

Transperineal ultrasound was performed on children with ulcerative colitis (UC) and children with other diseases, and data were collected. The results showed that the active UC group had predominantly thicker bowel walls and increased blood flow signals compared to the inactive UC group. This showed that transperineal ultrasonography is extremely useful for rectal lesion follow-up after endoscopic diagnosis of UC. In addition, transperineal ultrasound Doppler examination demonstrated a characteristic blood flow pattern in UC compared to other diseases, and a significant difference in statistical evaluation compared to other diseases, suggesting that transperineal ultrasound is useful not only for follow-up but also for diagnosis in rectal lesions of UC.

Free Research Field

小児消化器疾患

Academic Significance and Societal Importance of the Research Achievements

炎症性直腸病変の評価において経会陰超音波検査像は大腸内視鏡検査(CF)像との強い相関がみられたため、経会陰超音波検査はその簡便で低侵襲な検査であるという特徴から、潰瘍性大腸炎(UC)の直腸病変の評価において第1選択となり得ることが示唆された。また、UCに特徴的な血流シグナルを同定したことにより、UC患者における直腸炎がUCの再燃か感染症の合併によるものかを鑑別できるようになり、治療選択や治療効果の経時的モニタリングを容易とすると考えられる。また、社会的意義として、経腹壁と経会陰超音波検査により全大腸の超音波評価が可能となることでCFの件数が削減され、医療コストの削減にも寄与すると考えられた。