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2023 Fiscal Year Final Research Report

Development and Analysis of Novel Transdermal Immunotherapy Using Nanoparticles for Food Allergy

Research Project

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Project/Area Number 20K16918
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52050:Embryonic medicine and pediatrics-related
Research InstitutionUniversity of Fukui

Principal Investigator

Itoh Naohiro  福井大学, 学術研究院医学系部門(附属病院部), 特命助教 (90791905)

Project Period (FY) 2020-04-01 – 2024-03-31
Keywords食物アレルギー / 免疫療法 / ナノ粒子
Outline of Final Research Achievements

The purpose of this study was to elucidate the mechanism of food allergy remission. As a means to achieve this, we aimed to establish a novel transdermal immunotherapy by administering nanoparticles transdermally.
However, mice in the control group without nanoparticles also showed spontaneous remission (outgrowth) on multiple occasions. We decided that it was necessary to investigate the cause of the outgrowth in order to provide transdermal immunotherapy, so we focused on clarifying the mechanism of the outgrowth. We conducted a cross-sectional study in humans as a possible mechanism of the outgrowth and published our findings on the possibility that antigen-specific IgD is involved (Itoh N. Allergy. 2021).

Free Research Field

小児科

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、未だ解明できていない食物アレルギーの耐性獲得の機序解明に繋がる可能性を秘めている。現在検討している抗原特異的IgDは、その意義自体が近年まであまり明らかではなく、今後明らかにされることで食物アレルギーに限らず、アレルギー疾患全般に貢献する可能性がある。
社会的にも、現在アレルギー疾患は2人に1人は持つと言われており、その影響は大きい。本研究課題である食物アレルギーも、誤食によるアナフィラキシーが生命の危機を招いたり、社会的に問題となるいじめに発展することも報告されており、その食物アレルギーの治療の発展が社会的にも大きな意義を持つ。

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Published: 2025-01-30  

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