2022 Fiscal Year Final Research Report
Pathophysiology of neurological disorder associated with neonatal chronic lung disease focusing on ion homeostasis in neurons
| Project/Area Number |
20K16920
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52050:Embryonic medicine and pediatrics-related
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 超低出生体重児 / イオンホメオスタシス |
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| Outline of Final Research Achievements |
Chronic lung disease is one of major complications in extremely low birth weight infants, which is caused by high concentrations of oxygen and/or positive pressure ventilation, but its neurodevelopmental effects are not understood.
Loop diuretics are often used as adjunctive therapy for chronic lung disease (CLD). Loop diuretics inhibit both KCC2 and NKCC1, Cl- transporters present in neuronal membranes. Immature neurons are NKCC1-dominant, but as they mature, they change to KCC2-dominant.
In this study, we investigated the effects of CLD and loop diuretics on KCC2/NKCC1 expression and elucidated the resulting neurodevelopmental consequences.
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| Free Research Field |
新生児学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究によって、CLDの影響およびループ利尿薬の投与によるKCC2/NKCC1の発現の変化、またそれによる神経発達への影響が解明された。
本成果は、超低出生体重児、特にCLDを合併する児の神経学的予後を改善する管理に繋がると思われる。
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