Development of endoscopic bandage using a new bioabsorbable sheet

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K16946
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Hokkaido University
• Principal Investigator: Ono Masayoshi 北海道大学, 大学病院, 特任助教 (90845322)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 生体吸収性シート / ハイドロゲル / ESD / 内視鏡治療 / 後出血 / 穿孔 / 潰瘍

Outline of Final Research Achievements

In recent years, endoscopic submucosal dissection (ESD), enabling resection of lesions of unlimited sizes, has gained popularity, yet attention has shifted to covering the postoperative wound to prevent complications. However, optimal methods for treatment and prevention have not been firmly established. One approach involves covering the wound with a polyglycolic acid (PGA) sheet, but its adoption is limited due to application difficulties and cost. To address this, we have developed an "endoscopic band aid" that combines a bioabsorbable sheet specifically designed for endoscopes with hydrogel. This innovation overcomes the challenges associated with conventional PGA sheets' endoscopic delivery and now allows for hydrogel administration through an endoscope.

Free Research Field

消化器内視鏡

Academic Significance and Societal Importance of the Research Achievements

今回開発している生体吸収性シート＋ハイドロゲルが臨床応用された場合、内視鏡治療による合併症が低下し、患者にとっての負担軽減、また医療費の抑制が可能となる。具体的には合併症率が高いと考えられる抗血栓薬内服者、透析患者の内視鏡治療後創部に対する適応として今後臨床応用を検討中である。さらには現在治療困難である、難治性潰瘍の保護、瘻孔閉鎖、また手術困難な消化管穿孔症例に対する治療などの可能性も秘めており、内視鏡治療自体が大きく革新することも十分考えられる。