2021 Fiscal Year Final Research Report
Analysis of immune mechanisms common to ulcerative colitis and primary sclerosing cholangitis to elucidate the mechanisms of disease formation.
Project/Area Number |
20K16979
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 53010:Gastroenterology-related
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Research Institution | Chiba University |
Principal Investigator |
Ohta Yuki 千葉大学, 医学部附属病院, 医員 (80831510)
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Project Period (FY) |
2020-04-01 – 2022-03-31
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Keywords | 潰瘍性大腸炎 / 原発性硬化性胆管炎 / CD4+T細胞 |
Outline of Final Research Achievements |
Ulcerative colitis (UC) is a disease of unknown cause in which inflammation occurs primarily in the intestinal tract. UC can lead to a variety of extraintestinal manifestations that worsen daily life and prognosis. Primary sclerosing cholangitis (PSC) is one of the extraintestinal manifestations of UC and is a chronic, progressive, bile duct-destroying disease of unknown cause. The purpose of this study is to elucidate the pathogenesis of this disease using CD4+ T cells, which are commonly involved in the immunokinetics of not only UC and PSC, but also PSC complicated UC. Gene expression profiling of peripheral blood CD4+ T cells from UC, PSC, PSC-merged UC and healthy subjects was performed. Variable expression of disease-specific immune-related molecules was observed in CD4+ T cells from UC and PSC, and both features were observed in PSC-associated UC.
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Free Research Field |
消化器内科
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Academic Significance and Societal Importance of the Research Achievements |
潰瘍性大腸炎(UC)と原発性硬化性胆管炎(PSC)はいずれも原因不明の難病であり、両疾患の合併例はそれぞれの単独例よりも生命予後が悪い。本研究ではUC、PSCおよびPSC合併UCに共通して免疫動態に関わるCD4+T細胞に注目し、その遺伝子発現プロファイリングを行った。UCとPSCのCD4+T細胞では疾患特異的な免疫関連分子の発現変動が見られ、PSC合併UCではその両者の特徴が認められた。このことから疾患特異性の高い新規バイオマーカーを探索し、特にPSC合併UCを早期診断し生命予後の改善に寄与できる可能性がある。
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