To identify the cause of achalasia, we conducted biopsies sampling from the circular muscle layer of LES during POEM .

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K17049
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Tottori University
• Principal Investigator: IKEBUCHI Yuichiro 鳥取大学, 医学部附属病院, 助教 (20743280)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 食道アカラシア

Outline of Final Research Achievements

Multiple medical institutions in Japan, including Tottori University Hospital, Showa University Koto Toyosu Hospital, Fukuoka University Hospital, The Jikei University Hospital, and affiliated institutions of the University of Tokyo, are conducting approved studies. The research focuses on patients who have undergone POEM for esophageal achalasia and achalasia-like diseases. Specimens have been collected total 110 specimens. These specimens are currently being analyzed. In addition, 16 specimens from the lower esophageal sphincter (LES) region of esophageal cancer patients at Tottori University Hospital are also undergoing analysis. The studies aim to enhance our understanding of esophageal achalasia and achalasia-like diseases by analyzing specimens from patients who received POEM treatment and comparing them with control groups.

Free Research Field

消化器内科

Academic Significance and Societal Importance of the Research Achievements

我々はLES部の内輪筋生検試料を用いてマイクロRNAの網羅的な解析を行ったところ、アレイによる定性解析において有意な変動を示すヒト由来のマイクロRNAに加えて、複数のヘルペスウイルス由来のマイクロRNAを発見した。本研究では食道アカラシアとヘルペスウイルス由来のマイクロRNAとの関連性を明らかにし、食道アカラシアの病態解明、新たな診断法の確立、さらには将来の創薬への応用に繋げることを期待し、現在解析を進めている。