Nutritional Management in Acute Heart Failure Syndrome

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K17122
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Fukushima Medical University
• Principal Investigator: Sato Takamasa 福島県立医科大学, 医学部, 助教 (60566545)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 慢性心不全 / カヘキシー / 栄養評価

Outline of Final Research Achievements

We aimed to determine the prognostic impact of resting energy expenditure (REE) in patients with heart failure (HF). A total of 1185 consecutive HF patients were enrolled. The study population was divided into two groups according to median REE and we compered the clinical characteristics between two groups. Also, we examined the value of REE to predict cardiac mortality in HF patients. Results: In all subjects, 966 were males, median age was 63 years. Median REE was 1178 kcal/day. Patients with low REE were older and had higher prevalence of female and anemia, lower body mass index, more impaired renal function, lower parameters of nutrition, higher levels of plasma type-B natriuretic peptide than those with high REE. Patients with low REE had significantly higher rates of cardiac mortality. Furthermore, REE was the independent predictor of cardiac events. Conclusions: REE is important predictor of cardiac mortality in patients with HF.

Free Research Field

循環器内科　心不全

Academic Significance and Societal Importance of the Research Achievements

国内外において継続した栄養評価および栄養介入がどのように患者アウトカムに影響するかは十分なエビデンスがなく、報告も極めて少ない。したがって、心不全患者における栄養指標の変化およびそれに基づく栄養管理についてはいまだ十分確立されておらず、本研究の成果は慢性心不全患者の継続した栄養指標及び管理を行うに際し、簡便かつきわめて有用な指標となりうる。また、様々な心不全治療介入によって栄養状態がダイナミックに変化しうる可能性があり、心不全の適切な介入の妥当性を評価しうる点でも意義は大きい。