Reseach on the evaluation of oxidative stress biomarkers in interstitial pneumonia

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K17211
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Iijima Yuki 東京医科歯科大学, 東京医科歯科大学病院, 特任助教 (60721553)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 酸化ストレス / dROM / BAP / 間質性肺炎

Outline of Final Research Achievements

The dROM test measuring oxidative stress and the BAP test measuring antioxidant capacity were performed on 67 interstitial pneumonia patients, and the relationship between these results and the disease status and prognosis of interstitial pneumonia were analyzed. The mean age of the population was 67 ± 11.6 years, the %FVC was 87.0 ± 21.0%, most of the patients were mild cases, and the median observation period after oxidative stress measurement was 555 days. dROM and BAP values had a mean value of 352 ± 77.7 CARRU and 2193 ± 368.4 μEq/L, respectively.
No significant correlation was found between dROM or BAP values and lung function, interstitial pneumonia markers, or 6-minute walk distance. There was also no significant association of dROM and BAP values with risk of death.

Free Research Field

呼吸器内科

Academic Significance and Societal Importance of the Research Achievements

間質性肺炎患者の集団において酸化ストレスと抗酸化力のいずれかが異常をきたしている割合が多い事が明らかになったが、その集団内における病勢反映、予後予測などのマーカーとしての有用性は示す事ができなかった。症例数が少ない事や軽症例が多かった事、観察期間が短かった事などが関与している可能性が考えらられ、更なる検討が必要である。