Mechanism of rena stem cell aging

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K17254
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53040:Nephrology-related
• Research Institution: Jichi Medical University
• Principal Investigator: Ono Kazutoshi 自治医科大学, 医学部, 臨床助教 (50867520)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 急性腎障害 / バイオマーカー / EGF / 尿細管再生

Outline of Final Research Achievements

In this study, we measured urinary Epidermal Growth Factor (EGF) levels in patients with acute kidney injury (AKI) (n=99) using ELISA, and examined its association with the severity of tubular injury and renal outcomes. Compared to healthy individuals, urinary EGF was significantly decreased in AKI patients (14522 ± 2190 vs 3201 ± 459.7 pg/mL, p<0.05). In renal AKI, urinary EGF levels were significantly lower than in prerenal AKI. In AKI stage 3, urinary EGF levels were significantly lower than in AKI stage 1. There was no significant correlation between serum EGF and urinary EGF. Based on these findings, urinary EGF appears to be a useful non-invasive marker reflecting tubular repair after AKI.

Free Research Field

腎臓内科学

Academic Significance and Societal Importance of the Research Achievements

本研究により急性腎障害の診療における尿中EGFの重要性が示された。得られた知見は、「早期診断と病因の特定」「進行の監視と重症度の評価」「薬物の投与や調整のガイド」「予後の予測とリスクの評価」など様々な場面で活用できると思われる。バイマーカーと他の臨床情報（症状、身体所見、検査結果など）とを組み合わせた総合的な判断により、急性腎障害の診療レベルのさらなる向上が期待できると思われる。