2022 Fiscal Year Final Research Report
Evaluation of regulatory T cells in antibody mediated rejection using a rat kidney transplant model.
| Project/Area Number |
20K17260
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53040:Nephrology-related
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 腎移植 / 制御性T細胞 / 抗体関連型拒絶反応 / ラット腎移植 |
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| Outline of Final Research Achievements |
This study aims to elucidate the role and induction mechanism of regulatory T cells in antibody-mediated rejection. and In order to observe the time-dependent changes in chemokine receptors and regulatory T cells involved in tissue induction, we used a rat renal transplantation antibody-associated rejection model. Using a model of kidney transplantation into non-sensitized rats, the transplanted kidneys removed at day 7 were evaluated histopathologically. Infiltration of inflammatory cells into peritubular capillaries and glomeruli and deposition of complement (C4d) were confirmed. Anti-donor specific antibodies in sera were confirmed by flow cytometry. However, evaluation of chemokine receptors by immunostaining has been difficult.
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| Free Research Field |
腎移植
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| Academic Significance and Societal Importance of the Research Achievements |
本研究を通して、腎移植後の抗体関連型拒絶反応の発症機序の解明がより深まり、診断や治療への応用が可能になると考えられた。
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