2022 Fiscal Year Final Research Report
Monokine induced by gamma interferon levels in plasma is a sever diagnostic marker of Hydroa vaccniforme like lymphoproliferative disorder
| Project/Area Number |
20K17352
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | Epstein-Barr Virus / CXCR9/MIG / Hydroa vaccniforme / γδT細胞 |
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| Outline of Final Research Achievements |
The MIG of the plasma with cHV were significantly higher than that with sHV. A cut off level of MIG was set up at 152.1 pg/ml by using receiver operating curve (p=0.05), and both of the sensitivity and the specificity for the difference of cHV or sHV were 88.9% and 87.5%, respectively.We analyzed the plasma MIG (from 15.7 to 472.6 pg/ml) of the HV patient, whose phenotype shifted from cHV to sHV, were almost higher than the cut off level during her clinical courses. The other patient with sHV, who died of HPS, showed that the MIG levels of the plasma ranged from 1561.9 to 17175.8 pg/ml during her clinical course. The level of MIG was related to the level of IFNγ and CRP. A sHV patient showed a few MIG expression near the ulceration and many CXCR3 positive cells, which is ligand of MIG, infiltrated the skin lesions. But there were no expression of MIG and CXCR3 in cHV lesions.The plasma MIG levels might be associated with the systemic inflammation severity in the patients with HV.
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| Free Research Field |
Hydroa vaccniforme lymphoproliferative disorder
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| Academic Significance and Societal Importance of the Research Achievements |
血漿中のMIGは、現在HV-LPDの中に含まれているcHVとsHVを明確に分ける客観的基準値になりうると考える。またsHVの皮膚病変の病態がMIGとCXCR3によるIFNγの経路により形成されている可能性を考えると、皮膚病変の治療ターゲットとして上記経路の阻害剤を使用することで、皮膚病変の重症化を抑えうる可能性があり、今後のsHVの皮膚病変の治療選択の拡大につながる研究になると考えている。
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