2022 Fiscal Year Final Research Report
Adoptive immunotherapy for adult T-cell leukemia/lymphoma with ex vivo expanded multi-tumor associated antigen specific cytotoxic T-cells
Project/Area Number |
20K17375
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 54010:Hematology and medical oncology-related
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Research Institution | Nagoya University |
Principal Investigator |
Hanajiri Ryo 名古屋大学, 医学部附属病院, 助教 (40861810)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | 免疫療法 / 細胞療法 / 抗原特異的T細胞 / HLA / 臍帯血 / キメラ抗原受容体 |
Outline of Final Research Achievements |
This study focused on the target antigen, cell source, and metabolic state of T-cells to enhance the therapeutic efficacy of antigen-specific T-cell therapy targeting multiple antigens and chimeric antigen receptor gene transfer T-cell therapy for refractory hematologic malignancies including adult T-cell leukemia and lymphoma. It was suggested that overlapping peptides as antigens and umbilical cord blood as a cell source could be used for developing the adoptive immune T-cell product, and furthermore, manipulation of the intracellular metabolic state of T-cells could lead to improvement of T-cell function.
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Free Research Field |
血液内科学
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Academic Significance and Societal Importance of the Research Achievements |
養子免疫T細胞療法において、1)抗原エピトープが不明な場合でもオーバーラッピングペプチドによる抗原特異的T細胞の作製が可能であること、2)細胞源として成人と比較しより多くのナイーブT細胞が含まれる臍帯血が利用可能であること、3)T細胞の代謝制御による機能向上により、より高い抗腫瘍効果を発揮するT細胞製剤の開発につながる可能性がある。
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