Treatment of GVHD-related bone marrow failure with exosomes derived from AD-MSCs

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K17384
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 54010:Hematology and medical oncology-related
• Research Institution: University of the Ryukyus
• Principal Investigator: Nishi Yukiko 琉球大学, 病院, 助教 (60793924)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 脂肪組織由来間葉系幹細胞 / GVHD

Outline of Final Research Achievements

We isolated exosomes derived from AD-MSCs and examined their ability to produce antibodies in GVHD model mice treated with AD-MSCs. Mice with bone marrow GVHD showed significantly decreased antibody production, while mice with GVHD model mice treated with AD-MSCs showed increased antibody titers. The effect of bone marrow GVHD on immunocompetence and the improvement of immune function by AD-MSCs were observed.

Free Research Field

血液内科

Academic Significance and Societal Importance of the Research Achievements

骨髄GVHDが免疫能に与える影響及びAD-MSCによる免疫機能の改善を認めた。臨床において、同種造血幹細胞移植後GVHDの患者では、GVHD治療による免疫抑制のみならず、GVHDそのものによる免疫不全を呈している可能性が強く示唆される。