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2023 Fiscal Year Final Research Report

Functional elucidation of the histone modification enzyme SETDB2 in severe influenza virus infection

Research Project

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Project/Area Number 20K17469
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 54030:Infectious disease medicine-related
Research InstitutionNara Medical University

Principal Investigator

Imakita Natsuko  奈良県立医科大学, 医学部, 講師 (50865566)

Project Period (FY) 2020-04-01 – 2024-03-31
Keywordsインフルエンザウイルス / 脳症 / ヒストン修飾酵素 / SETDB2
Outline of Final Research Achievements

A comparison of serum SETDB2 in patients with influenza virus infection in the uncomplicated group and the group with encephalopathy or pneumonia showed that serum SETDB2 was significantly elevated in the group with encephalopathy or pneumonia. In addition, SETDB2 expression was found in tissue samples from autopsy cases of influenza encephalopathy and influenza pneumonia. These results suggest that SETDB2 is involved in the severity of influenza virus infection in humans. On the other hand, SETDB2 levels in sera from patients with novel influenza virus infection also tended to be elevated in more severe cases, suggesting that SETDB2 may be a common factor influencing the severity of viral infections.

Free Research Field

感染症

Academic Significance and Societal Importance of the Research Achievements

インフルエンザ脳症はインフルエンザウイルス感染症の重篤な合併症であり、致死率・後遺症残存率が未だ高いため、特異的な治療法の開発が望まれている。我々はインフルエンザ脳症マウスモデルを確立し、ヒストン修飾酵素の一つであるSET domain, bifurcated 2 (SETDB2)が重症化に関与していることを明らかにしてきた。今回、SETDB2の重症化予測マーカーとしての有用性に加え、重症化病態における役割について検討したところ、インフルエンザウイルス感染症においてSETDB2が重症化に関与しているとの結果であり、重症化予測マーカーとしてだけではなく新規薬剤の標的ともなりうることが期待できる。

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Published: 2025-01-30  

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