2021 Fiscal Year Final Research Report
extracellular elastic fiber regulate metabolism via interorgan
| Project/Area Number |
20K17495
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Keywords | 細胞外弾性線維 / エネルギー代謝 / 糖尿病 / 肥満 |
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| Outline of Final Research Achievements |
Fibulin5 (Fbln5), a matricellular secretory protein, is essential for the development of elastic fibers. We investigated Fbln5 knockout (Fbln5KO) mice fed a standard chow (SC) or a high fat (HF) diet to evaluate how extracellular elastic fibers regulate systemic metabolism.Fbln5KO mice showed enhanced insulin sensitivity and smaller body weight gain than wild-type mouse, and were protected against HF-induced hepatic steatosis. Moreover, Fbln5KO mice showed reduced cold tolerance and enhanced insulin transition via vasculature. Fbln5 deletion caused sebaceous glands atrophy in the skin in both SC-fed and HF-fed mice.
Thus, extracellular matrix protein Fbln5 might regulate systemic metabolism via multiple organ interaction.
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| Free Research Field |
代謝 糖尿病
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では細胞外弾性線維形成に必須の分泌蛋白Fibulin-5を介したエネルギー代謝制御機構について解析し、細胞外弾性線維とインスリン感受性制御や肥満の病態の関与を同定した。その詳細な分子機構の解明は、メタボリックシンドロームの新たな病態解明や治療開発に有用である。組織周辺環境による、臓器連関を介した代謝制御機構について提唱する。
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