2022 Fiscal Year Final Research Report
Do periodontal disease specific exosomes exacerbate diabetes?
| Project/Area Number |
20K17498
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | エクソソーム / 細胞外小胞 / microRNA / 糖尿病 / 歯周病 / 炎症 / インスリン抵抗性 / ナノ粒子 |
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| Outline of Final Research Achievements |
In recent years, it has been shown that periodontal disease affects the entire body-not just the oral cavity. Diabetes is a representative systemic disease. To investigate the relationship between periodontal disease and type 2 diabetes, we focused on insulin resistance caused by pro-inflammatory cytokines.To investigate this relationship from a new viewpoint, this study focused on exosomes, which are nano-sized particles secreted by cells.We used gingival keratinocytes, oral keratinocytes, periodontal ligament fibroblasts, macrophages, and osteoclasts as human periodontal tissue cells. These cells were used as exosome donor cells and/or recipient cells.
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| Free Research Field |
細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の意義は、これまで炎症性サイトカインや歯周病原性細菌のLPSを中心に議論されていた歯周病と2型糖尿病の病態関係を、エクソソームという全く新しい視点から解明することにある。その成果は、(1) 歯周病特異的・炎症特異的エクソソームを標的とした新らたな糖尿病・歯周病治療の道を開拓し、基礎となる考え方を確立すると期待され、(2) 血液や尿中のエクソソームによる糖尿病の合併症(歯周病)診断マーカーの開発や、(3) 唾液や歯肉溝滲出液中のエクソソームによる新規の歯周病診断基準の確立も可能にするであろう。
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