2021 Fiscal Year Final Research Report
regulatory mechanisms of energy metabolism controlled by the multilocular lipid droplets in brown adipocytes
Project/Area Number |
20K17510
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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Research Institution | Kobe University |
Principal Investigator |
Nishimoto Yuki 神戸大学, 医学研究科, 医学研究員 (20814320)
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Project Period (FY) |
2020-04-01 – 2022-03-31
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Keywords | FSP27β / 褐色脂肪細胞 / 脂肪滴 / エネルギー代謝 |
Outline of Final Research Achievements |
We generated FSP27βspecific knockout mice.FSP27β-KO mice did not differ from wild-type mice in body weight change or the white adipose tissue appearence, while brown adipose tissue showed monofocalization of multilocular lipid droplets. mRNA expression of Pgc1α and CideA, which are characteristic of brown adipocyte differentiation, was unchanged in FSP27β-KO mice compared with wild-type mice. Expression of mtTFA, which is associated with mitochondrial mass, was also comparable.This mouse will be used to further analyze how the multilocular lipid droplet morphology of brown adipose tissue itself affects energy metabolism.
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Free Research Field |
脂肪細胞
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Academic Significance and Societal Importance of the Research Achievements |
FSP27βは褐色脂肪細胞における多房性脂肪滴形態の維持に重要であることを個体レベルでも示した。FSP27β欠損マウスの褐色脂肪細胞の単房化が、個体の糖脂質エネルギー代謝にいかに関わるのか、今後さらに解析をすすめ、脂肪細胞における脂肪滴の形態とエネルギー代謝の普遍的な関係を明らかにしたい。
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