2021 Fiscal Year Final Research Report
The association between CRYM and PPAR gamma rising.
| Project/Area Number |
20K17529
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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| Research Institution | Shinshu University |
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Principal Investigator |
Okubo Yosuke 信州大学, 学術研究院医学系(医学部附属病院), 助教 (70793925)
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Keywords | 肥満 / 甲状腺ホルモン / 脂肪 |
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| Outline of Final Research Achievements |
Lack of μ-crystallin (CRYM), binding tri-iodothyronine, makes mice obese in feeding high-fat diets. The CRYM knock-out(KO) mice had fatty livers, and increasing fatty tissues. There was a high expression of the PPAR γ gene in their liver. To reveal the mechanism, we put the mice under hypothyroidism and hyperthyroidism. CRYM KO mice had more white adipose tissue than wild-type mice did under both situations. Furthermore, hypothyroidism made feeding amount decrease though, the CRYM KO mice had fatty livers. These results mean that there are other obesity mechanisms being non-related to thyroid hormones.
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| Free Research Field |
肥満、甲状腺ホルモン
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| Academic Significance and Societal Importance of the Research Achievements |
我々は甲状腺ホルモン結合蛋白μクリスタリン(CRYM)を研究する中で、CRYM欠損が肥満を呈することを見出してきました。もともと甲状腺ホルモンの低下は脂肪沈着や脂肪肝といった代謝の低下を起こすことが知られており、CRYMの肥満の機序はホルモンの影響と考えられていました。しかし、今回の研究でCRYMの肥満の機序の一部が甲状腺ホルモンに関連しない事実が得られました。現時点でCRYMと直接関連した肥満の経路の解明には至れていませんが、CRYMが甲状腺ホルモンを介さない独自の肥満機序があることが示唆され、新規の肥満機序の解明、肥満症の発展につながる可能性を示唆しています。
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