Research on novel therapeutic methods for breast cancer based on epithelial-mesenchymal transition

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K17589
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55010:General surgery and pediatric surgery-related
• Research Institution: Nagoya City University
• Principal Investigator: Yasuaki Uemoto 名古屋市立大学, 医薬学総合研究院(医学), 助教 (50818747)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 乳癌 / ASNS

Outline of Final Research Achievements

We investigated the relationship between ASNS mRNA expression and clinicopathological factors or prognosis in breast cancer patients. We found no relationships between ASNS mRNA expression and metastasis and prognosis. We also found that high ASNS mRNA expression was associated with ER-positive, HER2-negative, low-grade tumors and invasive lobular carcinoma, which are considered to have a favorable prognosis.

Free Research Field

乳癌

Academic Significance and Societal Importance of the Research Achievements

ASNSが乳癌の転移に関与し、予後に影響を与えるという仮説のもと本研究を計画したが、ASNS mRNA発現と乳癌の転移・予後との間に関連を認めなかった。上皮間葉転換（EMT）を介した乳癌転移の抑制は重要な課題であり、ASNSが乳癌に与える影響については更なる文献的考察・研究が必要である。