Does sedative administration have a protective effect against monocytic cell phagocytic dysfunction caused by endoplasmic reticulum stress?

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K17843
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: IIDA JUN 京都府立医科大学, 医学(系)研究科(研究院), 助教 (20515283)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 小胞体ストレス / 単球 / ARRDC4

Outline of Final Research Achievements

The administration of anesthetic drugs did not demonstrate an effect in reducing endoplasmic reticulum stress in monocytic cells during sepsis. Monocytic cell dysfunction is associated with apoptosis induced by endoplasmic reticulum stress, prompting further investigation into glucose response genes. TXNIP, a glucose response gene, has been found to be related to endoplasmic reticulum stress, and we focused on ARRDC4, which shares the highest sequence similarity with TXNIP and is primarily located on the cell membrane. Previous findings suggest that inhibiting protein interactions between ARRDC4 and GLUT1 may mitigate the increase in endoplasmic reticulum stress associated with ARRDC4 elevation.

Free Research Field

分子細胞学

Academic Significance and Societal Importance of the Research Achievements

単球系細胞は自然免疫と獲得免疫をつなぐ重要な働きを担い炎症消退において大きな役割を果たしている。この働きについて近年分子細胞学的に明らかとなったαアレスチンファミリーがどのように影響しているか、またそれを制御してゆくかについて明らかにしている。