Clarification of the ideal coil surface for coil embolization using CFD analysis

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K17922
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Kanazawa University
• Principal Investigator: Uno Takehiro 金沢大学, 附属病院, 特任助教 (10805154)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 脳動脈瘤 / CFD / コイリング後の再発 / Pressure difference

Outline of Final Research Achievements

We studied the ideal coil surface with a low recurrence rate. We have focused on the high pressure at the virtual coil plane after coiling, which was reported to be strongly associated with recurrence. However, further validation was needed to determine whether measurements at the virtual coil plane could predict recurrence. We used a vascular model that reflects the actual coil plane, created from post-coiling data, and found that high pressure was strongly associated with recurrence. We found that high pressure was strongly related to recurrence, and although previous reports have focused on internal carotid aneurysms, the same trend was observed in anterior communicating artery aneurysms. The results suggest the possibility of elucidating the coil plane with the lowest recurrence rate by seeking the coil plane with lower pressure.

Free Research Field

脳神経外科学

Academic Significance and Societal Importance of the Research Achievements

今回の成果で仮想コイル面における高い圧力がコイリング後の再発と強く関わっている事の検証がなされ、信頼が高まった。仮想コイル面における圧力は術前に測定可能であり、再発リスクの予測ができる。術前にコイリングによる再発の可能性が高いと予想された症例には、クリッピングなどの他の治療法に切り替える事で、動脈瘤治療の成績向上に寄与できる。