Application of anti-HMGB1 m Ab in intracerebral hemorrhage-induced brain injury in common marmoset and elucidation of HMGB1 translocation mechanism

2022 Fiscal Year Research-status Report

• Project/Area Number: 20K17930
• Research Institution: Okayama University
• Principal Investigator: 王 登莉 岡山大学, 医歯薬学域, 助教 (40815693)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 抗体治療 / 脳出血 / マーモセットモデル / HMGB1

Outline of Annual Research Achievements

本研究では霊長類マーモセット脳出血モテルにおけるヒト化抗 HMGB1 抗体の効果の確認と血腫吸収メカニズムの解明を目的とした。論文の原稿を作成し、投稿して、出版済みである。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

既に、投稿して、出版済みである。

Strategy for Future Research Activity

2023年12月に開催予定の第95回日本薬理学会年会で研究成果を発表する予定。

Research Products

• [Journal Article] Treatment of Marmoset Intracerebral Hemorrhage with Humanized Anti-HMGB1 mAb (2022)
  • Author(s): Dengli Wang, Daiki Ousaka, Handong Qiao, Ziyi Wang, Kun Zhao, Shangze Gao, Keyue Liu, Kiyoshi Teshigawara, Kenzo Takada, Masahiro Nishibori
  • Journal Title: Cells Volume: 11 Pages: 1-22
  • DOI: 10.3390/cells11192970
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Histamine induced high mobility group box-1 release from vascular endothelial cells through H1 receptor (2022)
  • Author(s): Shangze Gao, Keyue Liu, Wenhan Ku, Dengli Wang, Hidenori Wake, Handong Qiao, Kiyoshi Teshigawara, Masahiro Nishibori
  • Journal Title: Front Immunol . Volume: 13 Pages: 1-15
  • DOI: 10.3389/fimmu.2022.930683
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High-mobility group box 1-mediated hippocampal microglial activation induces cognitive impairment in mice with neuropathic pain (2022)
  • Author(s): Kazue Hisaoka-Nakashima, Kazuto Ohata, Natsuki Yoshimoto, Shintarou Tokuda, Nanako Yoshii, Yoki Nakamura, Dengli Wang, Keyue Liu, Hidenori Wake, Takayuki Yoshida, Yukio Ago, Kouichi Hashimoto, Masahiro Nishibori, Norimitsu Morioka
  • Journal Title: Exp Neurol . Volume: 355 Pages: 1-
  • DOI: 10.1016/j.expneurol.2022.114146
  • Peer Reviewed
• [Remarks] Research Map (王 登莉)
  • URL: https://researchmap.jp/okayaku2017