Suture Augmentation Does Not Change Biomechanical Properties and Histological Remodeling of Tendon Graft in Anterior Cruciate Ligament Reconstruction: A Study in a Porcine Model

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K17996
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Shinshu University
• Principal Investigator: Tensho Keiji 信州大学, 学術研究院医学系, 准教授 (20419378)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 前十字靭帯損傷 / 前十字靭帯再建 / 補強糸 / リモデリング / 豚 / 力学試験 / 組織学的評価

Outline of Final Research Achievements

The initial safety of ultra-high molecular weight polyethylene suture augmentation (SA) was evaluated in a porcine anterior cruciate ligament (ACL) reconstruction model. 10 pigs were divided into two groups for ACL reconstruction with and without SA, and biomechanical and histological evaluation was performed 12 weeks after surgery. SA did not affect anterior knee stability or structural properties of the grafted tendon, did not interfere with histological remodeling, and did not cause a foreign body reaction. The above was published in Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol. 39, No. 4, pp. 1014-1024.

Free Research Field

整形外科

Academic Significance and Societal Importance of the Research Achievements

本研究によりブタ前十字靭帯再建においてUHMWPE縫合糸による補強は、膝前方安定性や移植腱の構造特性に影響を与えず、組織学的リモデリングを妨げず、異物反応を引き起こさないことが明らかになった。本研究の結果は、SAを用いたACL再建術の有用性を検証するための更なる臨床研究の基礎となる。