2021 Fiscal Year Final Research Report
Elucidation of the role of JAG1 in muscle invasive bladder cancer with squamous differentiation
| Project/Area Number |
20K18093
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 56030:Urology-related
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2020-04-01 – 2022-03-31
|
| Keywords | 膀胱癌 / 扁平上皮分化 / JAG1 |
|---|
| Outline of Final Research Achievements |
We analyzed the role of JAG1 in squamous differentiation, a common histological subtype of muscle invasive bladder cancer, focusing on JAG1, a ligand of the NOTCH signaling pathway. Gene expression analysis and histopathological studies were conducted.
Gene expression analysis of MIBC in untreated and preoperative chemotherapy cohorts suggested an association between high JAG1 expression and enhanced TNFα signaling.In the preoperative chemotherapy and additional immune checkpoint therapy cohorts, high JAG1 expression was suggested to be a predictive marker of therapeutic resistance.
It will be interesting to clarify how ligand JAG1 expression is associated with receptor NOTCH signaling activity and related to prognosis and treatment response.
|
| Free Research Field |
泌尿器腫瘍
|
| Academic Significance and Societal Importance of the Research Achievements |
ゲノム医療やビッグデータを用いた個別化医療が身近なものとなりつつある現状において、筋層浸潤膀胱癌患者において、術前の組織を用いた化学療法感受性や抵抗性を事前に知り得ることは不要な化学療法による、手術待機時間の短縮や合併症発生率の低下につながる。
膀胱癌患者の個別化治療に向けた重要な知見の一つとなり得る。
|
