2022 Fiscal Year Final Research Report
Elucidation association between penile cancer and human papillomavirus using whole genome sequencing
Project/Area Number |
20K18099
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 56030:Urology-related
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Research Institution | Iwate Medical University |
Principal Investigator |
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | 陰茎癌 / ゲノム |
Outline of Final Research Achievements |
We extracted DNA from two penile cancer and normal specimen of the case corresponding to it, respectively, and conducted all genome sequences. 81,103 genomic aberrations of two penile cancer were found and were 43,416 and 37,687 per patient. 306 abnormality (201 and 105) in the protein coding region of those. Two insertion (one and one) which frame shift mutation happens, two deletion (two and 0) that frame shift mutation occurs, four deletion (three and one) that frame shift mutation does not occur and five changes (five and 0) which cause stop codon were detected. The genome structural abnormality was found in 275 places and was 182, 93 places per 1 case.
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Free Research Field |
泌尿器科
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Academic Significance and Societal Importance of the Research Achievements |
陰茎癌のwhole genome sequencingを用いたゲノムワイド解析はいまだされておらず,本研究が草分け的な研究である。陰茎癌の病態の解明および他のヒトパピローマウイルス(HPV)関連癌と比較することは非常に有用と考える。今後も継続して陰茎癌のwhole genome sequencingを用いたゲノムワイド解析を行いHPVとの関係について解明していく。
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