2023 Fiscal Year Final Research Report
A new strategy for preventive treatment of recurrent / refractory cystitis with lactic acid bacteria biosurfactant
| Project/Area Number |
20K18117
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56030:Urology-related
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | クオラムセンシング |
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| Outline of Final Research Achievements |
In our previous basic/clinical studies, we have focused on lactic acid bacteria endemic to the vagina and found that biosurfactants produced by them function as QS inhibitors. In addition, several peptides (especially Aggregation-promoting factor) in L. crispatus supernatant were predicted to have antimicrobial activity, indicating that they may be another antimicrobial mechanism in L. crispatus, in addition to lactic acid and hydrogen peroxide.
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| Free Research Field |
感染症
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| Academic Significance and Societal Importance of the Research Achievements |
膣に常在する乳酸菌に注目し、それが産生するバイオサーファクタントがクオラムセンシング阻害剤として機能することを見出している。また、L. Crispatus上清に含まれるいくつかのペプチド(特にAggregation-promoting factor)が抗菌活性を持つと予測され、乳酸や過酸化水素に加え、L. crispatusのもう一つの抗菌機構である可能性が示された。
反復性/難治性膀胱炎に対するクオラムセンシング阻害剤の臨床応用が期待される。
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