2022 Fiscal Year Final Research Report
Involvement of HOTAIR in renal cancer progression
| Project/Area Number |
20K18131
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56030:Urology-related
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 腎癌 / HOTAIR / non-coding RNA / IGFBP2 |
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| Outline of Final Research Achievements |
Previous studies have found that the HOTAIR-IGFBP2 pathway is involved in the malignant transformation of renal cancer, especially its migratory ability.Among the findings clarified in previous studies, we focused on the protein IGFBP2 that is induced by HOTAIR overexpression.A protein (CMF1) that specifically binds to IGFBP2 could be identified by proteome analysis.nvestigating the relationship between IGFBP2 and CMF1 in the future may lead to new therapeutic targets.
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| Free Research Field |
腎癌
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| Academic Significance and Societal Importance of the Research Achievements |
代表者はnon-coding RNAの一つであるHOTAIRが腎癌悪性化にIGFBP２タンパク質と関連して働くことを先行研究で報告しいる。本研究ではIGFBP2タンパク質がどのようなタンパク質と結合するかを調査し、腎癌悪性化に関わる機序をさらに追求した。今回得られた知見により、新たなる治療標的の開発につながる可能性がある。
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