Investigation of mechanism of bladder cancer formation by molecular analysis of field change bladder urothelium.

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K18139
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56030:Urology-related
• Research Institution: Osaka University
• Principal Investigator: Hayashi Yujiro 大阪大学, 医学系研究科, 招へい教員 (20804412)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 遺伝子変異 / 膀胱癌 / 発癌 / field change

Outline of Final Research Achievements

In bladder cancer, driver mutations are reported to exist as field changes in the mucosa without pathological evidence of malignancy, and are likely to be associated with tumor recurrence and bladder cancer development, but the molecular biological mechanism of field changes has not been elucidated. In this study, we performed a comprehensive gene mutation analysis of the normal bladder mucosa to elucidate the mechanism of bladder cancer recurrence.
Mutational analysis of bladder normal mucosa collected from bladder cancer patients revealed TERT promoter, FGFR3, and CDKN2A mutations, all of which were identified in normal urothelium and are likely to be driver mutations in the genome evolution of bladder cancer.

Free Research Field

泌尿器癌

Academic Significance and Societal Importance of the Research Achievements

これまで明らかになっていなかった筋層非浸潤性膀胱癌の腫瘍形成に関わる遺伝子変異を同定できた。筋層非浸潤性膀胱癌と筋層浸潤性膀胱癌では異なる遺伝子プロファイルを持つ可能性が示唆され、治療法を考える上で異なるアプローチが必要となる可能性が示唆され、社会的意義は大きいと考えられる。