Evaluation of glaucoma using the PhNR based on electrophysiological techniques.

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K18385
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56060:Ophthalmology-related
• Research Institution: University of Miyazaki
• Principal Investigator: Hidaka Takako 宮崎大学, 医学部, 助教 (00751140)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: PhNR / レチバル / 網膜内層機能 / 緑内障 / 網膜電図

Outline of Final Research Achievements

The PhNR was measured in 76 control eyes and 90 eyes with primary open-angle glaucoma (POAG) including normal tension glaucoma (30 eyes in the early stage and 60 eyes in the moderate to advanced stage) using a RETeval hand-held electroretinogram (ERG) measuring device (LKC Technologies) with a less invasive skin electrode. We used 5 PhNR parameters (base to trough (BT), peak to trough (PT), 72msPhNR, W-ratio, and P-ratio). We also examined the correlation between the PhNR and retinal nerve fiber layer thickness measured by optical coherence tomography and visual field test. The results showed that PhNR correlated significantly with visual field and retinal nerve fiber layer thickness. BT had the best diagnostic performance in both early and moderate to advanced stages. No significant correlation was found between blood flow and the PhNR in this study.

Free Research Field

緑内障

Academic Significance and Societal Importance of the Research Achievements

本研究では緑内障の有無を調べる判別一次関数をPhNRパラメーターの中で最も診断能力が高かったBTで以下のように定量的に求めることができた。BT: 判別式 = 0.505 x BT + 2.017; 正で疾患あり。正解率 = 80.7%。 PhNRの閾値を出した報告はわれわれが調べた限りいまだなく、より定量的に緑内障の有無を調べることが可能となった学術的意義があると考えている。またPhNRをレチバルを用い測定したことにより、小児や緑内障術後の患者に対し簡便に網膜内層機能評価を行う足がかりとなった。将来的に視野検査が困難な症例に対する緑内障の評価法として発展させる社会的意義も見いだせた。