Development of Mg alloy with special surface coating independent of kidney metabolism

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K18407
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56070:Plastic and reconstructive surgery-related
• Research Institution: Tohoku University
• Principal Investigator: Sato Akimitsu 東北大学, 大学病院, 助教 (90623603)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: Mg合金 / 生体材料

Outline of Final Research Achievements

In the development of biodegradable osteosynthesis materials using magnesium, suppression of gas generation during decomposition is an issue to be solved.In this study, we focused on the fact that the initial decomposition reaction is suppressed by applying a film treatment to the alloy surface. Then, the degree of decomposition suppression was examined from the amount of gas generated.Although the composition of the corrosion-resistant film treatment and the actual number of gas generated are confidential, the film treatment significantly suppressed gas generation at all time points.This study suggests the usefulness of corrosion-resistant film treatment for optimizing the corrosion rate.

Free Research Field

形成外科

Academic Significance and Societal Importance of the Research Achievements

本材料は、骨折部を単に固定するだけでなく骨折治癒・骨形成を促進することが可能であり、多機能性生体材料となる可能性を有している。骨折の骨固定材料として、このような多機能性の材料は他に存在しないため、合金表面の特殊加工により金属分解によるガス発生を抑制できれば画期的な骨固定材の開発につなげることができる。Mg合金を用いた顔面骨用骨固定材は、とりわけ小児症例においては第一選択となる可能性が高い。形成外科のみならず幅広い領域での応用も可能であり、臨床的意義は大きい。