Oral biofilm inhibition or dispersal by bacterial supernatant

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K18485
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57020:Oral pathobiological science-related
• Research Institution: Kyushu Dental College
• Principal Investigator: Yamasaki Ryota 九州歯科大学, 歯学部, 助教 (70841998)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 口腔疾患 / 口腔ケア / 口腔病原細菌 / バイオフィルム / バイオサーファクタント

Outline of Final Research Achievements

Oral diseases such as dental caries and periodontal disease can affect anyone. These oral diseases have recently been recognized to cause serious and sometimes life-threatening systemic diseases. The purpose of this study is to search for effective components in substances secreted by bacteria, and to develop new oral care agents. Pseudomonas aeruginosa and Bacillus subtilis each secrete unique biosurfactants, which have been shown to exhibit high antibacterial activity against oral pathogenic bacteria.

Free Research Field

口腔微生物学

Academic Significance and Societal Importance of the Research Achievements

口腔病原細菌が引きおこす全身疾患に感染性心内膜炎や誤嚥性肺炎がある。これらは特にお年寄りに多く、超高齢化社会を迎える我が国では軽視できない問題となっている。身体面や精神面の問題で十分な口腔ケアが行えず、口腔環境が悪化し口腔疾患や全身疾患を招いている。ゆえに簡便にかつ安全に口腔ケアが行える薬剤の開発が求められており、本研究はそれらをターゲットとした重要な意義を担っている。