2022 Fiscal Year Final Research Report
Vascular network as a basis for dental pulp stem cell niche formation
| Project/Area Number |
20K18544
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57030:Conservative dentistry-related
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 歯髄 / Type H血管 |
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| Outline of Final Research Achievements |
It was found that Type H vessels in the pulp exist, but that the amount of these vessels decreases over time. The relationship between Type H blood vessels and hard tissue formation was also examined. Wild-type C57BL/6J mice (4w, 8w, and 12w) were calcein-labeled and labeled with neoplastic hard tissues, which were then immunostained with anti-endomucin antibodies. The results showed that many Endomucin-positive vessels were observed in the pulp and dentin just below the calcein-labeled neocortical tissue. This suggests that Endomucin vessels contribute to hard tissue regeneration in the dental pulp. A paper based on these results is currently being written and will be submitted to an English journal.Translated with www.DeepL.com/Translator (free version)
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| Free Research Field |
歯髄
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| Academic Significance and Societal Importance of the Research Achievements |
今回の研究結果より、歯髄を構成する血管ネットワークは硬組織形成に寄与することが示唆された。これは、象牙質の形成や歯髄幹細胞ニッチ形成を解明するための基礎となると考えている。
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