2022 Fiscal Year Final Research Report
Development of inhibit denture using new photoreacted MPC polymer
| Project/Area Number |
20K18566
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 57040:Regenerative dentistry and dental engineering-related
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2020-04-01 – 2023-03-31
|
| Keywords | MPCポリマー / UV |
|---|
| Outline of Final Research Achievements |
This study focuses on the excellent biocompatibility, protein adsorption inhibition, and cell attachment inhibition of 2-methacryloyloxyethyl phosphorylcholine (MPC), an organic polymer that has been widely applied in the medical field. The purpose was to develop a denture.
In this study, we developed an MPC copolymer using camphorquinone, developed a polymer that can be used to coat the denture base with a dental irradiator in the clinical setting, confirmed the coating, tested anti-biofilm, etc. Were planned to be performed sequentially.
Although a more efficient method could be investigated by modifying the conventional coating method, a new MPC was not developed.
|
| Free Research Field |
バイオマテリアル
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究により，従来の煩雑な操作が必要であるMPCコーティングをより簡便で手軽な操作により同程度のコーティングが行えることが示唆された．従来チェアサイドではMPCコーティングは操作的に困難であると思われていたが，より小型化された装置と新しく合成されたポリマーを使用することで，チェアサイドでも手軽にコーティング操作が行えるようになった．
このことから，高齢者や要介護者などの義歯の衛生状態が不良になりやすい患者さんに対し，MPCコーティングを行うことで簡便に義歯を汚れない状態で保存させることができる可能性がある．
|
