2022 Fiscal Year Final Research Report
Investigation of transcriptional activity of microbiota for causing peri-implantitis
| Project/Area Number |
20K18567
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 57040:Regenerative dentistry and dental engineering-related
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2020-04-01 – 2023-03-31
|
| Keywords | インプラント周囲炎 / 細菌叢 / メタトランスクリプトーム / 機械学習 / ディープラーニング |
|---|
| Outline of Final Research Achievements |
Within microbiota around a dental implant, certain types of bacterial genes were highly expressed at the transcription level, whereas their expressional changes were not apparent during the passage of several weeks. On the other hand, bacterial taxa responsible for gene expression showed diversity among patients with respect to their proportions and changing patterns. These observations suggest that the bacterial gene expression changes with time passage within the peri-implant microbiota, whereas changes of bacterial taxa responsible for gene expression with time passage are diverse. In addition, samples of microbiota at oral disease lesions could be distinguished by applying machine learning.
|
| Free Research Field |
口腔細菌学
|
| Academic Significance and Societal Importance of the Research Achievements |
インプラント周囲に生じる複合感染症であるインプラント周囲炎については、インプラント体を埋入した時点で炎症が生じていなくても、細菌叢において何らかの病的な変化を経ることによって炎症の発症につながることが示唆される。本研究で明らかにした、インプラント周囲細菌叢における細菌の遺伝子転写発現やそれを主体的に担う細菌の種類の時系列的な変化は、細菌叢が将来的に病的変化するとすればそのもととなる状態と位置づけることができ、インプラント周囲炎の発症・進行をコントロールする上での基礎的情報となり得る。
|
