Development of periodontal regenerative therapy for horizontal bone defects and furcation involvements using 3D printer technology.

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K18571
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57040:Regenerative dentistry and dental engineering-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Fukuba Shunsuke 東京医科歯科大学, 歯学部附属病院, 非常勤講師 (50845625)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 歯周組織再生療法 / トランスレーショナルリサーチ / 炭酸アパタイト / ダイオードレーザー / 臨床研究 / FGF-2 / FGF-18 / インプラント周囲炎

Outline of Final Research Achievements

To explore the improvement of predictability in periodontal tissue regeneration therapy, we conducted various investigations from different aspects. Specifically, we conducted a retrospective cohort study to explore factors that affect the prognosis of periodontal tissue regeneration therapy. We verified the effectiveness of FGF-18 as a new growth factor and the effectiveness of carbonate apatite as a novel bone graft material through preclinical research and confirmed their effectiveness in clinical practice. We conducted a comprehensive investigation into the impact of diode laser on periodontal tissue. We also examined the resistance of bone graft materials to inflammation caused by differences in peri-implantiyid similar to periodontitis. Due to the limitations of the experimental period caused by the COVID-19 pandemic, it was currently impossible to develop bone graft materials using 3D printing technology.

Free Research Field

歯周病学分野

Academic Significance and Societal Importance of the Research Achievements

歯周病で失われた組織は歯周組織再生療法によって改善できるものの、その予知性や効果は不均一である。そこで新たな成長因子や骨補填材、手術手技の向上として、線維芽細胞増殖因子－18や、炭酸アパタイト顆粒、ダイオードレーザーなどの有効性の検証を網羅的に行なった。どれも歯周組織再生療法の予知性を高める可能性を示唆するものであり、今後の歯周組織再生療法に対するアプローチに関する研究において一助となり、実際の臨床場面において、歯周炎患者へ還元できるものと考えられる。