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2021 Fiscal Year Final Research Report

Elucidation of the effect of periodontal ligament fiber organization on stem cell differentiation as an extracellular microenvironment

Research Project

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Project/Area Number 20K18595
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57050:Prosthodontics-related
Research InstitutionNiigata University

Principal Investigator

Ida Takako  新潟大学, 医歯学系, 助教 (60790285)

Project Period (FY) 2020-04-01 – 2022-03-31
Keywords歯学 / 歯根膜 / Ⅴ型コラーゲン / 幹細胞分化
Outline of Final Research Achievements

In this study, I analyzed the effects of type V collagen as a factor controlling the extracellular microenvironment on the properties of extracellular matrix and the regulation of stem cell differentiation. Knockdown of COL5A1 by small interfering RNA (siRNA) affected gene expression and protein expression of lysyl oxidase (LOX) and type I collagen in periodontal ligament cells of rat. In addition, knockdown of COL5A1 suppressed gene expression of a differentiation marker (BMP2) in bone marrow-derived stem cells.

Free Research Field

歯科補綴学

Academic Significance and Societal Importance of the Research Achievements

本研究に期待される成果は、歯根膜恒常性維持機構の解明という観点から歯科医学に貢献するだけでなく、Ⅴ型コラーゲンによる線維形成と幹細胞分化制御機構の解明という観点から幹細胞生物学の発展に寄与する。Ⅴ型コラーゲンは幼弱な結合組織症状を呈する、エーラスダンロス症候群の原因遺伝子であるだけでなく、線維形成の亢進を伴う様々な病態における発現の亢進が認められる。したがって、その機能の解明は結合組織疾患の病態の理解の一端に寄与するものであると考えられる。

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Published: 2023-01-30  

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