The impact of salivary inflammatory markers on the development of metabolic syndrome

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K18629
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Osaka University
• Principal Investigator: Kosaka Takayuki 大阪大学, 歯学研究科, 助教 (40755360)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 口腔機能 / 老年 / 歯周病 / 循環器病 / メタボリックシンドローム

Outline of Final Research Achievements

This study assessed the relationship between oral health and general health in a Japanese urban population. Below results were found; 1. Declines in objective masticatory performance are associated with salivary stress markers. 2. Deterioration of periodontal status affects declines in masticatory performance. 3. Lower masticatory performance is a risk factor for the development of the metabolic syndrome. 4. Lower maximum bite force is a risk factor for developing cardiovascular disease.

Free Research Field

歯科補綴学

Academic Significance and Societal Importance of the Research Achievements

動脈硬化やメタボリックシンドロームをはじめとする循環器疾患のリスク因子としては、歯周病の罹患や口腔機能の低下が考えられる。本研究では、歯周病と口腔機能における相互の関わりを示すことができただけでなく、それらを多面的に評価し動脈硬化やメタボリックシンドロームとの関連を明らかにしたことで、口腔健康と循環器疾患との関連についての新たな基礎資料を多く得ることができた。