Involvement of myokine as a mechanism for controlling oral carcinogenesis and metastasis by exercise

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K18674
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Kagoshima University
• Principal Investigator: Yoshimura Takuya 鹿児島大学, 医歯学域鹿児島大学病院, 助教 (30726758)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 口腔癌 / サルコペニア / フレイル / 生存 / myokine

Outline of Final Research Achievements

It was found that the muscle mass of the sternocleidomastoid muscle and the fattening of the muscle around the vertebral spinous process affect the prognosis in patients with oral cancer, suggesting that it may be useful for prognosis prediction. In addition, in an experiment of transplanting an oral cancer cell line into an immunodeficient mouse, it was found that exercise suppresses the engraftment and proliferation of the oral cancer cell line and prolongs the survival period of the mouse. In the experiment of adding myokine to the oral cancer cell line, it was found that the effect differs depending on the type of myokine, and that there is myokine that affects the growth and migration of the oral cancer cell line.

Free Research Field

口腔外科学

Academic Significance and Societal Importance of the Research Achievements

頭頸部癌患者の骨格筋量および質が生命予後に影響することがわかっただけでなく、頭頸部CTの撮影範囲にある筋肉が選出されたことで経過観察にも有用である可能性ある。また、動物実験の結果を踏まえると、運動による口腔癌予防効果や発癌後も積極的に運動を行うことが生命予後を改善する可能性があることが示唆された。そのメカニズムにmyokineが関与する可能性も示唆されており、治療薬としてmyokineを利用できる可能性もある。口腔癌だけでなく、多くの疾患の予防にとって適度な運動重要であり、健康寿命の延伸に向けて運動の重要性がさらに強調された。