Elucidation of the role of periodontal pathogens in the invasion and metastasis mechanisms of oral cancer.

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K18692
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Osaka University
• Principal Investigator: Nishiyama Kyoko 大阪大学, 歯学部附属病院, 医員 (70846542)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 口腔癌 / 歯周病原菌 / 浸潤・転移 / 癌微小環境

Outline of Final Research Achievements

Recently, periodontal disease has been suggested to be a risk factor for the development of oral cancer, and periodontal pathogens are thought to be one of the causes. We treated SAS cells, a human oral squamous cell carcinoma cell line, with periodontal pathogen P. gingivalis and analyzed them using a next-generation sequencer. The Cancer Genome Atlas (TCGA) data were used to examine prognostic factors. The high expression of BMPER, SEMA3A, and TMSB15B genes significantly decreased the survival rate in TCGA-HNSCC data.

Free Research Field

口腔癌

Academic Significance and Societal Importance of the Research Achievements

近年、歯周病疾患は口腔癌の発病リスクファクターとなることが示唆されており、歯周病原菌が原因の一つと考えられている。本研究によって、BMPER、SEMA3A、TMSB15B遺伝子の高発現は TCGA-HNSCC 患者の生存率低下と密接に関連することが明らかになった。その中でも、TMSB15Bは歯周病原菌と関連したHNSCC患者の予後を予測する有望なバイオマーカー遺伝子としての可能性が期待される。