The elucidation of the bone microenvironment regulatory mechanism by IGFBPs and application to new treatment of bone-resorption disease

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K18716
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Hirosaki University
• Principal Investigator: Ito Ryohei 弘前大学, 医学部附属病院, 講師 (20638902)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 骨代謝 / 骨微小環境 / 癌微小環境 / 骨浸潤 / 骨吸収 / 空間的遺伝子発現解析

Outline of Final Research Achievements

By the expression of IGFBPs analysis of bone associated cells, IGFBP1 - 6 developed with time lag, and concentrations changed in the bone microenvironment, in sync with the change of the bone metabolism activity factor represented by ALP.IGFBPs behaved that controlled convergence from ossiferous initiation, and the possibility that IGFBPs would control bone metabolism was suggested.
As a result, a cancer cell and cancer-related fibroblasts, a signal network of the myofibroblast were reinforced, and it was suggested interactions were strengthened in the carcinomatous infiltration layer, and to act for the gene expression of bone association cells.

Free Research Field

口腔外科

Academic Significance and Societal Importance of the Research Achievements

本研究により骨微小環境はIGFBPsを調節することにより骨吸収性疾患と癌の骨浸潤・骨転移に関与する可能性が示唆された。さらに、癌の骨浸潤・骨転移には骨微小環境と癌微小環境という2つの微小環境の相互作用が影響していると考えられた。このことから、骨/癌微小環境を標的とした癌の骨浸潤・骨転移の新規治療法につなげていくことも可能であると考えられる。