Elucidation of alveolar remodeling mechanism mechanobiological analysis

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K18776
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Takeshi Ogasawara 東京医科歯科大学, 東京医科歯科大学病院, 助教 (50844669)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 歯科矯正学 / 矯正学的歯の移動 / 骨代謝 / 有限要素解析 / メカノバイオロジー

Outline of Final Research Achievements

In the histological,the alveolar bone surface around the periodontal ligament (PDL) was rough and TRAP-positive cells were observed diffusely along the PDL on the compression and traction sides at 1-, 2- and 3-day waiting periods. ALP-positive cells were not clearly observed. In finite element analysis, mesial tipping with a resistance center around the distal root was observed, and it was same result in animal experiment.In the integrated analysis, the contour image of stress distribution corresponding to each histological sections were extracted with a certain degree of accuracy, but differences in the geometry of the PDL were observed.
These results suggest that TRAP/ALP-positive cells are not categorized by the compression or traction side of loading during early tooth movement, and they may exhibit a complex correspondence pattern that is not a 1:1 relationship with the stress value.

Free Research Field

歯科矯正学

Academic Significance and Societal Importance of the Research Achievements

研究開始当初に目的としていた、歯槽骨のリモデリングを惹起する歯根膜のメカニカルストレスの解明には至らなかったが、それらの関係性は想定以上の複雑性を孕むことが明らかとなったため、歯の移動結果は単純な荷重の大小で決定されないことを示す一つの基盤となった。また研究過程において得られた知見から派生した矯正歯科臨床における歯の圧下移動の最適荷重条件の研究は、実臨床に直結する知見であると考える。