2021 Fiscal Year Final Research Report
Investigation of the interaction between FAK and selective autophagy and Establishment of effective treatment for temporomandibular joint disorders with regulation of selective autophagy
Project/Area Number |
20K18781
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 57070:Developmental dentistry-related
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Research Institution | Hiroshima University |
Principal Investigator |
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Project Period (FY) |
2020-04-01 – 2022-03-31
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Keywords | 変形性顎関節症 / オートファジー / 軟骨 |
Outline of Final Research Achievements |
Autophagy is a recycling system that breaks down unwanted substances in cells and is an essential function for survival. It is thought that when the function of autophagy declines with aging, many proteins aggregate and eventually lead to cell degeneration and apoptosis. The cell growth rate of temporomandibular joint cartilage is slow, and it is speculated that the role of autophagy is important for maintaining cell homeostasis and function. The purpose of this study was to clarify the relationship between temporomandibular joint-osteoarthrosis (TMJ-OA) and autophagy. As a result, it was clarified that autophagy decreased in TMJ-OA.
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Free Research Field |
矯正・小児系歯学
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Academic Significance and Societal Importance of the Research Achievements |
本研究で変形性顎関節症時にオートファジー機能を退化させる因子が特定され低下するメカニズムが解明された。変形性顎関節症においてオートファジーの低下を防ぐことで変形性顎関節症の新規治療法確立につながる可能性が示唆された。高齢者はオートファジーが低下していると報告されており、本研究の目的が達成されオートファジーが維持されれば、歯科領域疾患に留まらず、変形性膝関節症や関節リウマチなど、高齢者の関節疾患の予防および治療につながる可能性があり、医学的発展に影響を与えることが期待できる。
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