Elucidation of the actual status of drug-resistant bacteria/resistance gene invasion in humans in the market and evaluation of the risk of transmission

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K18925
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58020:Hygiene and public health-related: including laboratory approach
• Research Institution: Rakuno Gakuen University
• Principal Investigator: Fukuda Akira 酪農学園大学, 獣医学群, 講師 (90827320)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 薬剤耐性菌 / モニタリング / ESBL / フルオロキノロン / ST131 / パンデミッククローン

Outline of Final Research Achievements

We will elucidate the prevalence (concentration) and characteristics of resistant bacteria/resistant genes in the intestinal tract of humans in the city, and elucidate the actual situation of infiltration. Furthermore, in order to investigate the spread between hospitals and city hospitals, we will conduct molecular epidemiological analysis of city and hospital isolates to elucidate the dynamics of resistant bacteria/resistant genes in and out of hospitals. From these data, we will clarify the actual situation of infiltration of resistant bacteria in the city, as well as the risk of maintenance and transmission, and obtain knowledge useful for the control of resistant bacteria in and outside of hospitals. Currently, we are clarifying the chronological variation and invasion of resistant bacteria in the city.

Free Research Field

薬剤耐性菌

Academic Significance and Societal Importance of the Research Achievements

ヒト社会において薬剤耐性菌は抗菌薬を使用する病院での調査、現状把握を主体として行われていた。本研究では通常の社会生活を送っている市中の健常者における薬剤耐性菌のトレンドと浸潤状況を明らかにした。
病院と市中は同様の耐性菌のトレンドが見られ、薬剤耐性菌のパンデミッククローンの市中での浸潤が特に大きな問題と考えられた。