A Clinical study: Measurement of concentration after taking Aspirin mini-tablet

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K19145
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58070:Lifelong developmental nursing-related
• Research Institution: Showa University
• Principal Investigator: Hida Noriko 昭和大学, 薬学部, 教授 (30621742)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: ミニタブレット / 剤形変更 / 院内製剤 / 小児臨床薬理学 / アスピリン / 川崎病 / 小児製剤

Outline of Final Research Achievements

Children with Kawasaki disease are prescribed aspirin powder as an antipyretic analgesic and antiplatelet drug. However, some of them　remains in the mouth, resulting in a bitter or sour taste. To address this concern, we developed aspirin mini-tablets with a diameter of 3 mm. In this study, we conducted a pharmacokinetic comparison study in healthy adults. Our findings revealed no significant differences in Cmax and AUC between the mini-tablets and the spray formulation. Although the pharmacokinetic results from adults cannot be directly applied to children, the results of this study are important for predicting pharmacokinetics.

Free Research Field

小児臨床薬理学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は他の治療薬にもミニタブレットの技術を応用できることから、散剤を上手に服薬できない小児の薬物治療が格段にスムーズになることが期待される。本研究の成果によって、日本の子どもにも服用しやすい剤形について、開発初期から働きかけを行うことができる可能性が高まる。