Elucidation of the mechanism of action of physiotherapy for postoperative residual pain and verification of its efficacy by multifaceted quantitative evaluation

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K19374
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Nakamura Kaori 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (50817632)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 遺残疼痛

Outline of Final Research Achievements

In a human study, pain was significantly greater in the severe fibrosis group versus the mild fibrosis group in patients with ACLR reconstruction, and physical activity scores were also significantly lower in the severe fibrosis group versus the mild fibrosis group. Synovial fluid at 3 or 4 days showed increased levels of inflammatory cytokines IL1β, IL6, and IFN-gammas in the severe fibrosis group. They found that severe IFP fibrosis worsened clinical outcome 3 months after ACLR and increased inflammatory cytokines in synovial fluid. In rats, we replicated physiotherapy, a model of fatty body pain under the patella and hydrorelease.

Free Research Field

整形外科学分野

Academic Significance and Societal Importance of the Research Achievements

現在、理学療法には術後遺残疼痛を克服できていないという課題がある。そこで、本研究では術後遺残疼痛に炎症サイトカイン上昇と線維化が関与するという、疼痛発生の機序の一端を解明し、またラットでの多角的定量評価をを確立した。本研究成果は高齢化社会を迎え、手術件数が増加している日本において術後遺残疼痛を改善することにより、健康寿命を延伸するための研究の礎と考えられる。そのことは学術的、社会的意義があると言える。