2022 Fiscal Year Final Research Report
Effects of nutraceuticals intake for muscle atrophy on brain BDNF
| Project/Area Number |
20K19465
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 59010:Rehabilitation science-related
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| Research Institution | Teikyo University of Science & Technology |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 脳由来神経栄養因子 / BDNF / HMB / 機能性食品 / 高齢者 |
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| Outline of Final Research Achievements |
HMB intake in this research project had no effect on body weight, skeletal muscle, or brain weight. There was also no change in the cross-sectional area distribution rate of muscle fibers. BDNF expression in brain and skeletal muscle was not different by HMB intake. On the other hand, a decrease in BDNF expression was observed in old mice compared to young mice. Since no effect was observed under the present intake conditions, we believe there is room for further investigation of the intake conditions. In addition, since it has been reported that HMB promotes improvement of muscle function when combined with exercise intervention, we believe that there is a need to establish a condition in which exercise is also used.
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| Free Research Field |
筋生物学
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| Academic Significance and Societal Importance of the Research Achievements |
本邦は高齢社会を迎えており、今後も高齢者は増加する一途である。高齢者は、筋機能や認知機能の低下を呈することが多く、さまざまなADLの低下を引き起こす要因となっている。そのため、筋機能や脳機能を効率良く改善することが重要な課題である。本研究課題では、HMB摂取によって脳及び骨格筋におけるBDNFの明らかな増加は見出せなかったが、摂取条件(摂取量や摂取期間など)の新たな検討課題を得ることが出来た。また、老齢マウスのBDNF量が減少していることが明らかとなった。 今後HMBの摂取方法や運動との併用など、脳のBDNFへの効果についてさらなる検討をすることにより、臨床に繋がる知見を得ることを目指したい。
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