2022 Fiscal Year Final Research Report
Examination of nutritional diet therapy for sarcopenia caused by anorexia focusing on nutritional balance.
Project/Area Number |
20K19659
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 59040:Nutrition science and health science-related
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Research Institution | Kio University |
Principal Investigator |
MURAKI ETSUKO 畿央大学, 健康科学部, 准教授 (80369157)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | 加齢 / 栄養素バランス / 食欲不振 / 高たんぱく質 / BCAA |
Outline of Final Research Achievements |
The purpose of this experiment was to find out the optimal nutrient intake balance to establish a nutritional diet that can effectively prevent sarcopenia in elderly people who cannot secure enough energy due to decreased appetite. Aged mice that had been drug-induced anorexia were fed diets with varying energy ratios of the three macronutrients (protein, lipid, and carbohydrate). As a result, many of the mice on the protein-rich diet died. It was found that the cause of this was the large influence of the administered drug. Aged mice that had not been induced anorexia were also fed diets with varying proportions of branched-chain amino acids (BCAAs). As a result, mice fed a diet rich in BCAAs had lower total energy intake.
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Free Research Field |
臨床栄養学
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Academic Significance and Societal Importance of the Research Achievements |
本研究で食欲不振の誘発に用いたCDDPは、腎機能低下を招くことが知られているが、高齢者では腎機能が低下していることが多く、本研究の結果から、腎機能が低下している高齢者に、サルコペニア予防として高たんぱく質の食事を推奨することの危険性がうかがえた。また、分岐鎖アミノ酸は筋肉合成を促すことが知られているが、本研究の結果から、分岐鎖アミノ酸を多く含む食事では、食欲低下を招くことが示唆された。このことから、サルコペニア予防を目的として、高齢者に分子鎖アミノ酸を多く含む健康食品(いわゆる「プロテイン」など)を安易に勧めることの危険性が考えられた。
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