Identification of environmental and genetic factors on long-term prognosis in elderly patients with diabetes in a large genomic cohort

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K19663
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Kyushu University
• Principal Investigator: Komorita Yuji 九州大学, 医学研究院, 共同研究員 (10816218)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 糖尿病 / コホート / 高齢

Outline of Final Research Achievements

It is important to prevent not only conventional vascular complications but also complications specific to diabetes in the elderly such as fractures, sarcopenia, frailty, cancer, and dementia in order to improve the healthy life expectancy and prognosis of elderly patients with diabetes. In this prospective genomic cohort study of elderly Japanese patients with diabetes, we examined the long-term effects of diet, exercise and pharmacotherapy and the development of diabetic complications on healthy life expectancy, life independence and life outcome. In this study period, using data at enrolment and a 5-year follow-up database, we reported on risk factors for the development of fragility fractures, a diabetic complication specific to the elderly, the impact of fragility fractures on life expectancy, and the impact of diet and food preferences on life expectancy and chronic kidney disease.

Free Research Field

糖尿病学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果により、高齢糖尿病患者の生命予後に影響する因子として、糖尿病血管合併症以外の併存疾患の重要性が示された。個々の高齢糖尿病患者において、栄養指導を含めた最適な治療モデルを構築することで、健康寿命、生命予後の延伸、さらに医療福祉費の軽減につながると考える。