2022 Fiscal Year Final Research Report
Validation of mechanism and nutritional methods to improve glucose metabolism in subcutaneous adipose tissue
Project/Area Number |
20K19680
|
Research Category |
Grant-in-Aid for Early-Career Scientists
|
Allocation Type | Multi-year Fund |
Review Section |
Basic Section 59040:Nutrition science and health science-related
|
Research Institution | Kyoto Prefectural University |
Principal Investigator |
|
Project Period (FY) |
2020-04-01 – 2023-03-31
|
Keywords | 褐色脂肪 / 熱産生ホルモン / 皮下脂肪 / FGF21 |
Outline of Final Research Achievements |
This study examined the effects of fibroblast growth factor 21 (FGF21), which is a thermogenic hormone, on subcutaneous adipose tissue using nutritional approaches. In animal studies, high-sucrose diet-induced FGF21 secretion did not enhance thermogenesis in subcutaneous fat, and had higher plasma glucose levels. Interventional human studies revealed that although fructose intake increased plasma FGF21 levels, the increased thermogenic hormone was not associated with adipose tissue thermogenesis. The results suggest that dietary-induced FGF21 secretion does not link to adipose tissue thermogenesis and glucose homeostasis.
|
Free Research Field |
健康科学
|
Academic Significance and Societal Importance of the Research Achievements |
近年、脂肪組織の褐色化を促進し、糖代謝の向上や抗肥満作用に働く熱産生ホルモンが関心を集めている一方で、熱産生ホルモンがヒトの代謝に及ぼす影響は十分に検証されていない。本研究は、果糖摂取により分泌促進が認められているFibroblast Growth Factor 21(FGF21)に着目し、その生理作用の解明に努めたが、結果としてFGF21によるヒトの脂肪組織および糖代謝へ影響は認められなかった。今後、本研究と同様の手法を用いて、他の新規内分泌因子と代謝機能との関連性を検証することにより、真に健康増進や疾病予防に役立つ因子の解明につながることが期待される。
|