Development of cell-containing porous material using novel cell transfer method and its application to tissue regeneration and three-dimensional cell culture

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K20198
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 90120:Biomaterials-related
• Research Institution: Shinshu University
• Principal Investigator: Negishi Jun 信州大学, 学術研究院繊維学系, 准教授 (60722634)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 多孔質材料 / 細胞導入 / 含浸技術 / 3次元培養

Outline of Final Research Achievements

Porous scaffolds with a large number of connected pores are used as base materials for tissue regeneration and cell culture. However, the problem is that the cells do not infiltrate some porous scaffolds. In this study, using impregnation techniques used in the fields of metals and food processing, a new method for introducing cells into polymer and biological porous scaffolds were established. Moreover, the cell-introduced scaffolds promoted tissue regeneration, and can also be used as a cell culture material.

Free Research Field

生体医工学・組織工学

Academic Significance and Societal Importance of the Research Achievements

本研究による様々な多孔質材料への細胞導入法の確立は、細胞の3次元培養や組織の再生への貢献が期待される。組織や臓器を模倣した材料を用いた3次元培養は、細胞機能の解明や創薬研究におけるスクリーニングへの応用につながる。また、患者自身の細胞を多孔質材料に導入する新たな治療法につながり、欠損した組織や臓器の再構築に貢献する。